controlled vocabulary with a hierarchical structure.

Get the latest public health information from CDC: https://www.coronavirus.gov.

Sci Rep. 2020 Sep 29;10(1):16041. doi: 10.1038/s41598-020-72708-x. HHS Cyclic redundancy and other checksums
Legend Epub 2014 Jun 2. Evidence that fungal MEP proteins mediate diffusion of the uncharged species NH(3) across the cytoplasmic membrane.

from the sequence. 2015 Jan;78:3-8. doi: 10.1016/j.yjmcc.2014.11.015.

Reconstitution of EmrE into small unilamellar vesicles. To examine the intracellular distribution of HA-EmrE, a functional chimera between HA-EmrE and the green fluorescent protein (HA-EmrE-GFP) was prepared. After solubilization and purification, the protein retains its ability to transport, as judged from the fact that it can be reconstituted in a functional form (45). In its absence, uniporter channel activity was lost despite intact MCU expression and oligomerization. Deletion of acidic amino acids conserved in EMRE did not significantly affect Ca(2+) uptake; thus, EMRE did not have basic properties of ion channels such as ion-selectivity filtration and ion concentration.

the US Department of Energy (DE-SC0019749),

The membrane insertion topology of the two monomers is controversial. Epub 2014 Nov 22. Epub 2020 Jun 29. iScience. Although the EmrE protein was reported to have a unique orienta ... EmrE, a multidrug transporter from Escherichia coli, functions as a homodimer of a small four-transmembrane protein. Single-pass membrane protein.

Schuldiner S, Lebendiker M, Yerushalmi H. BMC Plant Biol. PLoS One.

an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.

Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Wu W, Shen Q, Zhang R, Qiu Z, Wang Y, Zheng J, Jia Z. EMBO J. Nathoo S(1), Litzenberger JK, Bay DC, Turner RJ, Prenner EJ. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. Quantitative mass spectrometry of affinity-purified uniplex recovered MICU1 and MICU2, MCU and its paralog MCUb, and essential MCU regulator (EMRE), a previously uncharacterized protein.
2020 Jul 14;117(28):16383-16390. doi: 10.1073/pnas.2000640117. using the generator polynomial: x64 + x4 + x3 + x + 1. Calcium uniporter; EMRE; MCU; Mitochondria; Yeast. UniRef.
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emre protein

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EMRE is an essential component of the mitochondrial calcium uniporter complex. COVID-19 is an emerging, rapidly evolving situation. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Sequence clusters. Proc Natl Acad Sci U S A. 2013;8(2):e55785.

EmrE is a highly hydrophobic 12-kDa protein that has been purified by taking advantage of its unique solubility in organic solvents. COVID-19 is an emerging, rapidly evolving situation.

GeneRIFs: Gene References Into Functions.
It is useful for tracking sequence updates.



The expression of EMRE alone was insufficient for Ca(2+) uptake; and co-expression of MCU with EMRE was necessary. Using this expression system, we analyzed the essential MCU regulator (EMRE), which is a key subunit for Ca(2+) uptake but whose functions and structure remain unclear.

EmrE protein Imported Gene names i: Name:emrE Imported.

The conserved C-terminal tail is strongly coupled to EmrE's drug-binding domain and participates in secondary gating of EmrE-mediated proton/drug transport, occluding the binding pocket of fully protonated EmrE in the absence of drug to prevent dissipative proton transport (PubMed:30287687). Epub 2020 Aug 7.

The membrane insertion topology of the two monomers is controversial.

Protein knowledgebase. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCU. Mitochondrial Calcium Uniporter (MCU) deficiency reveals an alternate path for Ca.

COVID-19 is an emerging, rapidly evolving situation. 2000 Apr;182(8):2307-10. doi: 10.1128/jb.182.8.2307-2310.2000.

STRING allows inspection of the interaction evidence for any given network.

Domain architecture, phylogeny and membrane association of EMRE, Fig. Get the latest public health information from CDC: https://www.coronavirus.gov. EMRE is a 10-kilodalton, metazoan-specific protein with a single transmembrane domain. USA.gov. Epub 2014 Jun 2. 2020 Aug 7;3(10):e202000718. We'd like to inform you that we have updated our Privacy Notice to comply As yeast cells lack orthologues of the mammalian proteins, the yeast expression system for the mammalian calcium uniporter subunits is useful for investigating their functions.

The membrane insertion topology of the two monomers is controversial.

Reconstitution of the mitochondrial calcium uniporter in yeast. 5 Publications

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Using Cu2+ ions or methylamine, we could selectively permeabilize the plasma membrane or deplete the proton electrochemical gradients across the vacuolar membrane, respectively.

 |  NIH Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.

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This section provides any useful information about the protein, mostly biological knowledge.

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UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure.

Get the latest public health information from CDC: https://www.coronavirus.gov.

Sci Rep. 2020 Sep 29;10(1):16041. doi: 10.1038/s41598-020-72708-x. HHS Cyclic redundancy and other checksums
Legend Epub 2014 Jun 2. Evidence that fungal MEP proteins mediate diffusion of the uncharged species NH(3) across the cytoplasmic membrane.

from the sequence. 2015 Jan;78:3-8. doi: 10.1016/j.yjmcc.2014.11.015.

Reconstitution of EmrE into small unilamellar vesicles. To examine the intracellular distribution of HA-EmrE, a functional chimera between HA-EmrE and the green fluorescent protein (HA-EmrE-GFP) was prepared. After solubilization and purification, the protein retains its ability to transport, as judged from the fact that it can be reconstituted in a functional form (45). In its absence, uniporter channel activity was lost despite intact MCU expression and oligomerization. Deletion of acidic amino acids conserved in EMRE did not significantly affect Ca(2+) uptake; thus, EMRE did not have basic properties of ion channels such as ion-selectivity filtration and ion concentration.

the US Department of Energy (DE-SC0019749),

The membrane insertion topology of the two monomers is controversial. Epub 2014 Nov 22. Epub 2020 Jun 29. iScience. Although the EmrE protein was reported to have a unique orienta ... EmrE, a multidrug transporter from Escherichia coli, functions as a homodimer of a small four-transmembrane protein. Single-pass membrane protein.

Schuldiner S, Lebendiker M, Yerushalmi H. BMC Plant Biol. PLoS One.

an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.

Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Wu W, Shen Q, Zhang R, Qiu Z, Wang Y, Zheng J, Jia Z. EMBO J. Nathoo S(1), Litzenberger JK, Bay DC, Turner RJ, Prenner EJ. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. Quantitative mass spectrometry of affinity-purified uniplex recovered MICU1 and MICU2, MCU and its paralog MCUb, and essential MCU regulator (EMRE), a previously uncharacterized protein.
2020 Jul 14;117(28):16383-16390. doi: 10.1073/pnas.2000640117. using the generator polynomial: x64 + x4 + x3 + x + 1. Calcium uniporter; EMRE; MCU; Mitochondria; Yeast. UniRef.

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